TRP Research Group

Group leader:

  • Dr. István Balázs Tóth, Ph.D.

Members of the research group:

  • Dr. Erika Lisztes, Ph.D.
  • Dr. Árpád Kunka, M.D.,Ph.D. student
  • Márk Racskó, M.Sc., Ph.D. student
  • Dr. Judit Bohács, Dent.D., Ph.D. student

A short summary of the scientific work carried out by the research group:
Our working group studies the molecular regulation, physiological and pathophysiological role, and pharmacology of TRP ion channels. We primarily investigate the expression, function and role of TRP channels in physiological and pathological conditions in in vitro systems, on different primary cells and cell lines.
The focus of our interest is the investigation of the role played by heat-sensitive TRP channels in somatosensory functions and inflammatory processes, primarily in the cells of human skin and dental pulp.

List of the most important publications related to the research work:

  1. Balázs, István Tóth; Bahar, Bazeli; Annelies, Janssens; Erika, Lisztes; Márk, Racskó; Balázs, Kelemen; Mihály, Herczeg; Tamás, Milán Nagy; Katalin, E. Kövér; Argha, Mitra; Attila, Borics; Tamás, Bíró; Thomas, Voets. (2024) Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants. eLife, accepted for publication IF:7.7 (2022)
  2. Árpád, Kunka; Erika, Lisztes; Judit, Bohács; Márk, Racskó; Balázs, Kelemen; Gabriella, Kovalecz; Etelka, D. Tóth; Csaba, Hegedűs; Kinga, Bágyi; Rita, Marincsák; Balázs István, Tóth. (2024) TRPA1 upregulation mediates oxidative stress in a pulpitis model in vitro. Br J Pharmacol., accepted for publication IF:7.3 (2022)
  3. Vincze A, Lisztes E, Szabó K, Béldi T, Nagy-Vincze M, Pór Á, Varga J, Dankó K, Bíró T, Tóth BI, Griger Z. (2023) Pruritogenic molecules in the skin of patients with dermatomyositis. Front Med. 10, 1168359, IF:3.9 (2022)
  4. Pénzes Z, Alimohammadi S, Horváth D, Oláh A, Tóth BI, Bácsi A, Szöllősi AG. (2023) The dual role of cannabidiol on monocyte-derived dendritic cell differentiation and maturation. Front Immunol. 14(14), 1-15, IF:7.3 (2022)
  5. Alimohammadi S, Pénzes Z, Horváth D, Gyetvai Á, Bácsi A, Kis G, Németh Á, Arany J, Oláh A, Lisztes E, Tóth BI, Bíró T, Szöllősi AG. (2023) TRPV4 activation increases the expression of CD207 (Langerin) of monocyte-derived Langerhans cells, without affecting their maturation. J Invest Dermatol. 143(5), 801-811, IF: 6.5 (2022)
  6. Ádám D, Arany J, Tóth KF, Tóth BI, Szöllősi AG, Oláh A. (2022) Opioidergic Signaling-A Neglected, Yet Potentially Important Player in Atopic Dermatitis. Int J Mol Sci. 23(8), 4140 IF:5.6
  7. Szöllősi AG, Oláh A, Lisztes E, Griger Z, Tóth BI. (2022) Pruritus: a sensory symptom generated in cutaneous immuno-neuronal crosstalk. Front Pharmacol. 13, 745658. IF:5.6
  8. Angyal Á, Pénzes Z, Alimohammadi S, Horváth D, Takács L, Vereb G, Zsebik B, Bíró T, Tóth KF, Lisztes E, Tóth BI, Oláh A, Szöllősi AG. (2021) Anandamide Concentration-Dependently Modulates Toll-Like Receptor 3 Agonism or UVB-Induced Inflammatory Response of Human Corneal Epithelial Cells. Int J Mol Sci. 22(15), 7776, IF:6.208
  9. Diszházi G, Magyar ZÉ, Lisztes E, Tóth-Molnár E, Nánási PP, Vennekens R, Tóth BI, Almássy J. (2021) TRPM4 links calcium signaling to membrane potential in pancreatic acinar cells. J. Biol. Chem. 297(3), 1-5, IF:5.486
  10. Held K, Tóth BI. (2021) TRPM3 in Brain (Patho)Physiology. Front Cell Dev Biol. 9:1-16. IF:6.081
  11. Kelemen B, Pinto S, Kim N, Lisztes E, Hanyicska M, Vladár A, Oláh A, Pénzes Z, Shu B, Vriens J, Bíró T, Rohács T, Voets T, Tóth BI. (2021) The TRPM3 ion channel mediates nociception but not itch evoked by endogenous pruritogenic mediators. Biochem Pharmacol. 183:114310. IF:6.1
  12. Tóth BI, Szöllősi A, Bíró T. (2021) TRP Channels in Itch and Pain. In: Itch and pain: similarities, interactions, and differences / Gil Yosipovitch, Hjalte Holm Andersen, Lars Arendt-Nielsen, IASP, Washington, 157-167, 2021. ISBN: 9781975153038
  13. Kelemen B, Lisztes E, Vladár A, Hanyicska M, Almássy J, Oláh A, Szöllősi AG, Pénzes Z, Posta J, Voets T, Bíró T, Tóth BI. (2020) Volatile anaesthetics inhibit the thermosensitive nociceptor ion channel transient receptor potential melastatin 3 (TRPM3). Biochem Pharmacol. 174:113826. IF:5.858
  14. Lisztes E*, Tóth BI*, Bertolini M, Szabó I, Zákány N, Oláh A, Szöllősi A, Paus, R., Bíró, T. (2019) Adenosine promotes human hair growth and inhibits catagen transition in vitro: role of the outer root sheath keratinocytes. J Invest Dermatol. 140 (5):1085-8. IF: 8.551 *These authors contributed equally to the work (shared first authorship)
  15. Szántó M, Oláh A, Szöllősi AG, Tóth KF, Páyer E, Czakó N, Pór Á, Kovács I, Zouboulis CC, Kemény L, Bíró T, Tóth BI (2019) Activation of TRPV3 Inhibits Lipogenesis and Stimulates Production of Inflammatory Mediators in Human Sebocytes – A Putative Contributor to Dry Skin Dermatoses. J Invest Dermatol. 139(1):250-3. IF: 7.143
  16. Kemény Á, Kodji X, Horváth S, Komlódi R, Szőke É, Sándor Z, Perkecz A, Gyömörei C, Sétáló G, Kelemen B, Bíró T, Tóth BI, Brain SD, Pintér E, Gyulai R (2018) TRPA1 Acts in a Protective Manner in Imiquimod-Induced Psoriasiform Dermatitis in Mice. J Invest Dermatol. 138(8):1774-84. IF: 6.290
  17. Bíró T, Oláh A, Tóth BI, Szöllősi AG (2018) Endogenous Factors That Can Influence Skin pH. Curr Probl Dermatol. 54:54-63.
  18. Szöllősi AG, Oláh A, Bíró T, Tóth BI (2018) Recent advances in the endocrinology of the sebaceous gland. Dermatoendocrinol. 9(1):e1361576.
  19. Ambrus L, Kelemen B, Szabó T, Bíró T, Tóth BI (2017) Human podocytes express functional thermosensitive TRPV channels. Br J Pharmacol. 174(23):4493-4507. IF: 6.81
  20. Janssens A*, Gees M*, Toth BI*, Ghosh D, Mulier M, Vennekens R, Vriens J, Talavera K, Voets T (2016) Definition of two agonist types at the mammalian cold-activated channel TRPM8. Elife. 5:e17240. IF:7.725 *These authors contributed equally to the work (shared first authorship)
  21. Tóth BI, Oberwinkler J, Voets T (2016) Phosphoinositide regulation of TRPM channels - TRPM3 joins the club! Channels (Austin). 10(2):83-5. IF:2.042
  22. Tóth BI, Konrad M, Ghosh D, Mohr F, Halaszovich CR, Leitner MG, Vriens J, Oberwinkler J, Voets T (2015) Regulation of the transient receptor potential channel TRPM3 by phosphoinositides. J Gen Physiol. 146(1):51-63. IF:4.511
  23. Tóth BI, Nilius B. (2015) Transient Receptor Potential Dysfunctions in Hereditary Diseases: TRP Channelopathies and Beyond. In: Arpad Szallasi (ed.) TRP Channels as Therapeutic Targets. Academic Press, 13-33.
  24. Tóth BI, Szallasi A, Bíró T (2015) Transient receptor potential channels and itch: how deep should we scratch? Handb Exp Pharmacol. 226:89-133.

 

Last update: 2024. 04. 02. 11:42